One newly funded project this year supports a project by Angela Schulz from the University Medical Center Hamburg-Eppendorf (UKE), DE in collaboration with Esther Sammler, MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, UK.
The project aims to analyze the lysosomal proteome and metabolome (metabolites and lipids) in CLN3 patient peripheral blood mononuclear cells (PBMCs), to identify disease-specific changes in patients that may also serve as biomarkers in future clinical trials. At the UKE, lysosomes are purified from fresh PBMCs from CLN3 patients. The samples are frozen and stored at -80 degrees Celsius until they are shipped to the University of Dundee where part of the multi-omics analysis (proteomics) takes place, while the metabolome part is examined at Stanford University in the laboratory of Monther Abu-Remaileh.
Funding partners of the project are the Adalbert Zajadacz Foundation and the Helga
and Alfred Buchwald Foundation. Thank you very much!