research funding


Since 2002 we have been investigating the field of NCL research. We want to understand what causes this fatal disease. Our ambitious aim is to develop a therapy in order to be able to cure NCL. Therefore, the € 50,000 NCL research award is awarded each year to projects that contribute to curing NCL. Furthermore we fund scholarships with our donations. Worldwide we are the biggest single sponsor in this area. To react quickly to new developments, we also offer short-term start-up support. These short projects can be extended to larger ones where appropriate. And because there are many overlaps between childhood and adult dementia, the Neurodegeneration Award was initiated this year.

 

To recieve the latest news and information about NCL research regularly, feel free to sign up for our Research Newsletter. For questions on the subjects of research and development or funding please contact Dr. Herman van der Putten.

 

A compilation of all currently funded research projects can be found in our annual review.

Doctoral fellowships

Postgraduate and research scholarships are awarded for up to three years. Regular reports and visits to laboratories are part of the programme. Candidates for funding can be recommended by their supervisors followed by an interview with our research leader. Here, two of them present their projects: 

In Cooperation with Evotec, Daniela will test 2,000 compounds on a human CLN3 cell model and examine whether one of them can improve the condition of the defective neurons. Thanks to its infrastructure and many years of experience Evotec is the ideal partner to carry out high-throughput-screenings.


Supervisor: Dr. Guido Hermey, UKE, Hamburg
Funding Partners: Heinrich Hartmann Stiftung

Doctoral student Daniela Borchert
Doctoral student Daniela Borchert

Katarzyna studies how mitochondrial-lysosomal signaling differs in the absence of CLN3.The ultimate goal is to tease out metabolic consequences of CLN3-deficiency in the hope that this will generate new insights into perturbed pathways to be corrected and therapeutic approaches.


Supervisor: Dr. Nuno Raimundo, University Medical Center, Göttingen.
Funding Partners: dgroup, Hans Rosenthal Preis, HAORI-Stiftung Bremen, Heinz und Heide Dürr Stiftung, Online-Aktion von Julia Risel, von Poll GmbH.

Doctoral student Katarzyna Wieciorek
Doctoral student Katarzyna Wieciorek

Heart problems are a typical accompanying disease of NCL. In her research project, Emily is investigating cardiac muscle cells which host the NCL defect to find out their functionality.


Supervisor: Dr. Katja Rietdorf, The Open University, Milton Keynes

Funding Partner: Batten Research Fonds, Bijou Brigitte Stiftung, Böttcher-Stiftung, NCL-Golf-Trophy, RT4 golf tournament, Stichting Beat Batten

Doctoral student Emily Coode
Doctoral student Emily Coode

Gemma has successfully used the CRISPR/Cas method to produce hiPS cells with CLN3 mutations, which are similar to patients' cells but have the same genetic background. These cells form the basis for her studies and, have become important tools for other laboratories to test potential drugs.

 

Supervisor: Prof. Dr. Hans Schöler, Max Planck Institut Münster

Funding Partners: Batten Research Fonds,  Berti Vogts, Münster Krimi Cup

Gemma Gomez Giro researches on NCL
Gemma Gomez Giro researches on NCL

Application procedure & steps

  1. first contact our research leader Dr. Herman van der Putten or call +49 (163) 738 3083 to make sure the project is in line with our goals
  2. submit a letter of intent (see download below) to present the project briefly 
  3. based on this we will decide whether to ask you to submit a full proposal. Full proposals will be examined by the board, the scientific advisory board and other external reviewers of the NCL Foundation.
Download
Application Form (Fellowship)
2020-08-21 NCL Application Form (Fellows
Adobe Acrobat Dokument 800.4 KB

Deadline: 28th February and 31st August every year


NCL research award

Clinical-orientated projects are particularly prizeworthyThe prize money is used to fund postdoctoral fellows, to implement the submitted project and to promote young scientists. In order to find a cure for jNCL, scientists from all over the world are encouraged to submit their projects, especially those from related fields like Alzheimer's, ageing and lysosomal storage diseases.

The 10th NCL Research Prize was awarded in 2020 to the project "CLN3 metabolic function: from basic discovery to biomarker development" by Dr. Monther Abu-Remaileh from Stanford University, USA. It aims to develop biomarkers to support diagnosis and therapy of juvenile NCL, also known as CLN3. Having biomarkers available for NCL, and especially for CLN3, which is one of the most common forms, remains an unmet medical need today. However, they are essential as indicators to assess the progression and success of therapies during drug development. Monther Abu-Remaileh and his research group were able to detect a massive accumulation of specific metabolic degradation products in CLN3 diseased cells. When normal CLN3 function is restored, cell recovery is observed. In preclinical studies, the researchers now want to test whether the amount of these metabolic degradation products in the cells can serve as a significant biomarker for CLN3 disease.

 

Funding Partner: Joachim Herz Stiftung.

Prof. Dr. Monther Abu-Remaileh, recipient of the 10th NCL Research Award. Copyright: Monther Abu-Remaileh
Prof. Dr. Monther Abu-Remaileh, recipient of the 10th NCL Research Award. Copyright: Monther Abu-Remaileh

Application procedure & steps

  1. first contact our research leader Dr. Herman van der Putten or call +49 (163) 738 3083 to make sure the project is in line with our goals
  2. submit a letter of intent to present the project briefly 
  3. based on this we will decide whether to ask you to submit a full proposal. Full proposals will be sent out for peer review to at least two reviewers. We welcome recommendations for independent expert reviewer candidates, as well as proposals for exclusion due to potential conflict of interest.

Neurodegeneration Award

Thanks to the great support of  the Joachim Herz Stiftung,  we were able to announce another €100,000 grant. The so-called Neurodegeneration Award 2018 covers a postdoctoral fellowship salary for two years. The aim is to foster and improve synergies in resarch into NCL childhood dementia and age-related neurodegeneration. Two laboratories from the above-mentioned fields must apply jointly. The postdoctoral fellow should thus have the opportunity to conduct research in both laboratories to ensure the exchange of respective expertise.

The "Neurodegeneration Research Award" 2018, endowed with 100,000 euros, goes to two neuroscientists from Munich and Boston: Sabina Tahirovic, from the German Center for Neurodegenerative Diseases e.V. (DZNE) and Susan Cotman, from Massachusetts General Hospital, will use the prize money to research commonalities between dementia in children and adults.

 

The focus of the two-year project are the immune cells of the brain. For all their differences, childhood dementias share a number of similarities with Alzheimer's disease. These include the activation of the brain's immune cells, known as microglia. As a result, chronic inflammation develops. The scientists want to understand how the microglia change in childhood dementia and why they enter a state of permanent activation.

 

On this basis, new targets for therapy are to be found, which could also be explored with regard to the treatment of Alzheimer's disease.

from left to right: Dr. Frank Stehr, managing director NCL-Stiftung, award winners Dr. Susan Cotman and  Dr. Sabina Tahirovic and Dr. Henneke Lütgerath, chairman of the board of Joachim Herz Stiftung. Source: DZNE / Volker Lannert.
from left to right: Dr. Frank Stehr, managing director NCL-Stiftung, award winners Dr. Susan Cotman and Dr. Sabina Tahirovic and Dr. Henneke Lütgerath, chairman of the board of Joachim Herz Stiftung. Source: DZNE / Volker Lannert.

Short Projects

Funding proposals can also be requested for smaller projects. These projects shoud consist of research intended for practical application intended to form the basis of new projects.

NCL locations worldwide
NCL locations worldwide