Since 2002 we investigate in the field of NCL research. We want to understand what causes this fatal disease. Our ambitious aim is to develop a therapy in order to be able to cure NCL in future. Therefore the 50.000 € NCL research award is awarded each year to projects that contribute the healing of NCL. Furthermore we fund scholarships with our donations. Worldwide we are the biggest single sponsor in this area. To react fast to new developments we give as well short-termed start-up support. These short projects can be extended to bigger ones where appropriate. And for there are many interfaces between childhood and adult dementia, the Neurodegeneration Award was initiated this year.
To get the latest news and informations about NCL research regularly, feel free to sign for our Research Newsletter. Concerning questions on the subjects research and development or funding please contact Dr. Herman van der Putten.
Postgraduate and research scholarships are award up to three years. Regular reports and visits in laboratories are part of the program. Candidates for a funding can be recommended by there supervisors followed by an interview with our research leader. Here two of them present their projects:
Abuzar has studied the interaction between the CLN3 protein and another protein which is associated with the Alzheimer form of adult dementia in more detail. He is currently working to finish this reesearch before submitting it for publication. He has created important molecular tools which will now benefit other NCL laboratories.
Supervisor: PD Dr. Guido Hermey, Centre for Molecular Neurobiology Hamburg
Funding Partner: Dorit & Alexander Otto Stiftung
Gemma has succcessfully used the CRISPR/Cas method to produce hiPS cells with CLN3 mutations, which are similar to patients´cells but have the same genetic background. These cells form the basis for her studies and are, in the meantime important tools for other laboratories to test potential drugs.
Supervisor: Prof. Dr. Hans Schöler, Max Planck Institut Münster
Funding Partners: Batten Research Fonds, Berti Vogts, Münster Krimi Cup
Particularly prizeworthy are innovative clinical-orientated projects. The prize money is used to fund postdoctoral fellows, to implement the submitted project and to promote young scientists. In order to find a cure for jNCL, scientists from all over the world are encouraged to hand in their projects, especially those from related fields like Alzheimer, ageing and lysosomal storage diseases. The last two awardees in brief:
Dr. Thomas Wishart and his PhD student Maica Llavero Hurtado (University of Edinburgh) were the lucky winners of this year’s NCL research award. The objective of their research project is to identify new approaches for an effective therapy against NCL with the help of the 50.000 € prize money. Since there are indications that communications between NCL patients’ neurons are faulty, the team is focusing on neurons’ control centres, the synapses.
Funding Partner: ADM Hamburg AG, Online-Campaign "Save the Brain", HanseMerkur Recognition Award for Child Protection, Münster Krimi Cup
The 6th NCL research award went to Dr. Christian Michael Grimm (Pharmazie Department LMU Munich). Dr. Grimm and his team are developing new methods to investigate the role of membrane proteins - like the NCL protein CLN3 - in the lysosome and to identify therapeutic substances, which can compensate the loss of CLN3.
Funding Partner: IMS Health GmbH & Co. OHG, Lieselotte-Paulsen-Stiftung, Online-Campaign "Childhood memories“, United Charity
Thanks to the great support of the Joachim Herz Stiftung we are able to announce another 100.000 € grant. The so-called Neurodegeneration Award 2018 covers a postdoctoral fellowship salary for two years. The aim is to foster and improve synergies in reesarch on the NCL childhood dementia and age-related neurodegeneration. Therefore, applicants must meet the following requirements:
Ideally, postdoctoral candicates should conduct a considerable part of their work in both laboratories. Interested laboratories first send us a brief letter of intent (see download above). After acceptance you will be asked to send in a full proposal. Send The application form to email@example.com. Whether you need help to find a collaborating partner do not hesitate to contact us.
Funding proposals can also be requested for smaller projects. These projects should deal with translatory questions to launch new research projects.